Compliments from our sponsor charities & Partners
The 2016 Rock ‘N Run was fantastic! Congratulations on a wonderful event. I hope you are basking in the post-event afterglow! Mazel Tov on providing important breast cancer and ovarian awareness to our community.
“Turn your face to the sun and the shadows fall behind you.” -Maori ProverbCONGRATS on a truly spectacular event. It was phenomenal in every single way imaginable. As a proud, if incredibly saddened, part of Team Sune, I am happy to let you know that our team raised $600 for the 2016 Rock ‘N Run. The entire team could not be happier that the money raised in memory of Sune, exactly one week and a day following her passing last Saturday, far too young (age 28) from breast cancer, will go towards such meaningful causes.We are proud and humbled to have been part of such a special and healing day and just wanted to express enormous appreciation for the incredible effort and hard work that so clearly went into organizing the Rock ‘N Run by each of you and all the others directly invovled. We hope that all of you are soaring from the success and are fully aware of what an impact you made for so, so many today, none the least of which was our grateful and inspired Team Sune.
Cancer Link loves being a part of the Rock N Run! Below is a list of doctors to whom we have been donating money, plus four new projects for which we have provided funding.Marzenna Blonska, PhD – new projectThe major research area in my laboratory is to investigate the role of NF-kB and Jun signaling in lymphomagenesis. Both NF-kB and Jun are transcription factors that control hundreds of genes responsible for cell survival, proliferation and migration. Interestingly, my recent studies revealed the link between activated Jun signaling and lymphoma cell dissemination and interaction with the microenvironment. Using a combination of RNAi and cDNA microarray techniques with newly developed animal model of disseminated lymphoma, I plan to identify the major drivers of lymphoma progression and spread to the extranodal tissue (including immunoprivileged sites). It is anticipated that these studies will lead to the development of new biomarkers for B-cell lymphomas.Lluis Morey, PhD – new projectThe major aim in my laboratory is to understand the molecular mechanisms leading to cancer.Cancer is a genetic disease, which develops as a consequence of mutations in our genome. My laboratory is particularly interested in the identification and characterization of epigenetic factors deregulated during cancer initiation and progression. Epigenetics is defined, as heritable changes in gene expression that does not involve changes in the underlying DNA sequence, resulting in phenotype changes. DNA-methylation, histone modifications, and non-coding RNAs are the three main epigenetic mechanisms that initiate and sustain gene expression or repression. Therefore, we are also interested in elucidating the function of epigenetic genes mutated in cancer. Finally, we are using embryonic stem cells (ESC) as a tool to study early development programs and cellular differentiation. Interestingly, expression signatures that are specific to ESC are also found in many human cancers and in mouse cancer models, suggesting that these shared features might inform new approaches for cancer therapy. Our main projects include: (1) Identification and characterization of cancer driving mutations in epigenetic regulators, (2) Identification and characterization of novel non-histone methyltransferases substrates, (3) Role of epigenetic factors associated with tumor initiation, cancer progression and metastasis, (4) Cell fate modulation by Polycomb group proteins.Mingjiang Xu, MD, PhD – new projectNormal development of hematopoietic cells requires precise control of hematopoietic stem cell (HSC) self-renewal, proliferation, differentiation, and programmed cell death. Patient-derived gene alterations of epigenetic regulators (such as TET2, ASXL1 and PHF6) may perturb these processes leading to the development of hematological malignancies (both myeloid and lymphoid malignancies). Our laboratory is actively investigating the effect of TET2, ASXL1 or PHF6 loss on the pathogenesis of hematological malignancies utilizing both primary patient specimens and genetically modified mouse models. In addition, our lab is also evaluating novel therapeutics for subtypes of hematological malignancies. The ultimate goals of my research are: (1) to elucidate the cellular and molecular mechanisms of TET2-, ASXL1- and PHF6-inactivation mediated hematological malignancies, and (2) to identify novel therapeutic targets and develop effective therapies for these diseases.Feng-Chun Yang, MD, PhD – new projectMyeloid malignancies are a broad class of blood disorders, including myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN), myelodysplastic/myeloproliferative neoplasm (MDS/MPN), and acute myeloid leukemia (AML). In the past several years, numerous novel genetic lesions have been identified in patients with myeloid malignancies, which dramatically improved our understanding of the molecular basis of these diseases. However, an ultra-critical and challenging scientific question remains in the field of myeloid malignancies, which is to determine the role of each of these novel genetic lesions in the multi-step pathogenesis of myeloid malignancies and to clarify their underlining cellular and molecular mechanisms. The major goal of my laboratory is to elucidate the cellular and molecular mechanism of myeloid malignancies by investigating the effects of NF1 inactivation and/or ASXL1 gene alterations on the pathogenesis of myeloid malignancies utilizing both primary patient specimens and state of the art gene-modified mouse models.Joyce Slingerland, MD, PhDResearch focuses on molecular mechanisms of single transduction and hormone effects on cell cycle regulation and breast cancer cell growth, breast cancer stem cells as targets for therapy and the role of estrogen receptors in breast cancer.Diana Lopez, MDResearch focuses on the role of the tumor environment in the regulation of a protein called Matrix Metalloproteinase-9 or “MMP’9,” which is crucial in tumor invasion and metastasis and is implicated in leukocyte extravasation.Zafar Nawaz, PhDResearch focuses on mechanisms of steroid hormone receptor and coactivator action in normal and cancerous tissues, with important emphasis on estrogen receptor regulation in breast cancer and androgen receptor regulation in prostate cancer.Ralf Landgraf, PhDResearch focuses on identifying the mechanisms underlying ERBB receptor control. The deregulation of ERBB (HER) receptor tyrosine Kinases (EGFR, ERBB2, ERBB3 and ERBB4) is a widespread phenomenon in a broad range of cancers, but ERBB signaling has the potential to elicit cell proliferation, differentiation, migration and programmed cell death, and thus understanding the mechanisms understanding of ERBB receptor control will not merely “fill in the blanks” in our mechanistic models and better explain modes of action and limitations of existing treatments, but it will open up fundamentally new levels of regulatory control for targeted drug design.Tan Ince, PhDResearch focuses on the role of cell-of-origin in determining tumor phenotype and development of culture systems for in vitro culture of primary human tissues and tumors.
The Sandy B. Muller Breast Cancer Foundation is honored to have been the recipient of funds from the “Rock ‘n Run Think ‘n Feel Pink ‘n Teal” in 2013, 2014 and 2015. These generous donations were used to assist breast cancer patients in our community with their basic living expenses while receiving treatment for breast cancer. These patients are struggling financially, and with the support of the “Rock ‘n Run,” they were able to receive much-needed help. The foundation also was given the opportunity to raise awareness of breast cancer and our foundation’s mission. We are blessed to live in a community with so many amazing people who support these wonderful causes. Thank you to the Hollub and Wolf families for hosting and for including the Sandy B. Muller Breast Cancer Foundation in this wonderful community event.
Sharsheret is thrilled to partner with Rock ‘N Run Think ‘N Feel Pink ‘N Teal again this year and are appreciative for your ongoing support. At Sharsheret, we provide culturally-relevant and empowering resources to create the strongest, most personal chain of support for every Jewish woman and family facing breast and ovarian cancer. Here is a snapshot of the ways we are changing the cancer conversation through outreach and education:Informing the Young, Busy, and ActiveIt’s imperative that we arm active Jewish communities with the kind of cancer information they need. That’s why we introduced Sharsheret Teal and Pink Shabbat® synagogues of all denominations nationwide. Turning Shabbat teal and pink allows us to teach participants the importance of learning their family cancer history in a supportive and meaningful environment.Supporting Survivors and Women At-Risk or DiagnosedWhen you’re faced with cancer, nothing is more empowering than knowledge. That’s why we host Health Care Symposia—a series of teleconferences, webinars, and roundtables, featuring experts in the field, aimed at Jewish women of all ages. The Health Care Symposia discuss unique issues women face while fighting cancer, such as dating, fertility, genetics, career, survivorship, body image, and more.Bringing Cancer-ed to Co-edsThe younger we educate, the healthier they stay! That’s why Sharsheret is focused on reaching college-aged kids. Our program, Have The Talk® parents about their family cancer history. Since 2012, more than 90,000 students have participated on 150 college campuses.Teaching Doctors, Social Workers, and Community LeadersIt’s not hard to find a health care professional who is well-versed in breast and ovarian cancer, but finding one who genuinely understands how these illnesses pose unique concerns for Jewish women can be very difficult. That’s why Sharsheret provides Cultural Competency Training Seminars for 600 health care professionals and community leaders annually.With your continued support, we are going to be able to reach more women, men, and families who need our help. We cannot thank you enough for all you have done and continue to do for Sharsheret.
Rock and Run plays an important role in the fight against breast and ovarian cancer by bringing passionate community members together to raise awareness about the diseases, while providing education and vital resources for local organizations serving women in our community. This effort helps to save and change lives. We are so honored to be a part of this incredible movement.
Thank you for your support of the Sandy B. Muller Breast Cancer Foundation for breast cancer patients in treatment. We were honored to be chosen again as one of the charities to benefit from the proceeds of the Rock ‘N Run Think N Feel Pink N Teal event at Beth Am on October 4th. I appreciated the opportunity to raise awareness of breast cancer and of our foundation’s mission with the many supporters at the event. I was thrilled to see so many friends and families in our community participate in the event and support the cause again this year. We are blessed to live in a community with so many amazing people who support these wonderful causes. Thank you for your generous donation of $4,000 which will help us to provide Peace of Mind for women and men during their breast cancer journey.Since our service program began in November 2009, our foundation is proud to have assisted over 160 breast cancer patients in treatment.The Sandy B. Muller Breast Cancer Foundation provides patients in Miami-Dade County recently diagnosed with breast cancer and in treatment with needed help with non-medical basic living expenses such as mortgage and rent payments, medical insurance premiums, transportation costs to and from doctors’ appointments, child care payments, food and other life necessities. Your personal efforts on our behalf will help us to provide Peace of Mind from financial hardship for these patients.Thank you for providing our foundation with the opportunity to partner with you during October, Breast Cancer Awareness Month, and we look forward to continuing to work with you in the future in any way we can.Warm regards,
Thank you and the Rock N’ Run family for another year of funds raised for much needed ovarian cancer research. We appreciate your continued support!
On behalf of Sylvester Comprehensive Cancer Center, I would like to thank you for forwarding the generous gift of $10,000 from the “Rock N Run” event designated for Breast Cancer Research.This year, Sylvester has continued its rapid pace of recruiting world-class researchers and expanding and enhancing its research programs. Our physicians and scientists are working diligently to treat patients, find new mechanisms to fight cancer, and expand our clinical trials program, which offers new treatments and hope for patients.Its takes a community to build a cancer center, and we are grateful for your support. Sincerely,
Thank you for your support of the Sandy B. Muller Breast Cancer Foundation for breast cancer patients in treatment. We were honored to be chosen again as one of the charities to benefit from the proceeds of the “Rock ‘N Run” event at Beth Am on October 12th. I appreciated the opportunity to raise awareness of breast cancer and of our foundation’s mission with the many supporters at the event. I was thrilled to see so many friends and families in our community participate in the event and support the cause again this year. We are blessed to live in a community with so many amazing people who support these wonderful causes. Thank you for your generous donation of $3,600 which will help to provide Peace of Mind for women and men during their breast cancer journey.Since our service program began in November 2009, our foundation is proud to have assisted over 130 breast cancer patients in treatment.The Sandy B. Muller Breast Cancer Foundation provides patients in Miami - Dade County recently diagnosed with breast cancer and in treatment with needed help with non-medical basic living expenses such as mortgage and rent payments, medical insurance premiums, transportation costs to and from doctors appointments, child care payments, food and other life necessities. Your personal efforts on our behalf will help us to provide Peace of Mind from financial hardship for these patients. Thank you for providing our foundation with the opportunity to partner with you during October, Breast Cancer Awareness Month and we look forward to continuing to work with you in the future in any way we can.Warm regards,
Congratulations to you and your family for hosting another fabulous Rock ‘N Run on Sunday. It is wonderful to see so many supporters from our community come out to support such great causes, Ovarian and Breast Cancer. I was happy to see many of my friends participating in the walk. I am honored to be part of this event and on behalf of the Sandy B. Muller Breast Cancer Foundation I thank you for inviting us.